Editorial Response: Estimating the True Cost of Amphotericin B
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چکیده
منابع مشابه
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A basic statistic that students learn about in their classes is the standard deviation. Like any statistic, standard deviations are influenced by systematic factors and randomness. I propose that researchers should report “corrected” or “true” standard deviations and I show how to calculate them. The notion of “true” statistics comes out of classical test theory (see Lord and Novick, 1968; Gull...
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Unilamellar liposomal amphotericin B (AmBisome) (liposomal AMB) reduces the toxicity of this antifungal drug. The unique composition of liposomal AMB stabilizes the liposomes, producing higher sustained drug levels in plasma and reducing renal and hepatic excretion. When liposomes release their drug payload, unbound, protein-bound, and liposomal drug pools may exist simultaneously in the body. ...
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Liposomal amphotercin B was compared with conventional amphotericin B for empirical antifungal therapy in febrile neutropenic patients in a randomized, double-blind, multicentre trial. Using a composite end-point, the two drugs were equivalent in overall efficacy. However, the liposomal amphotericin B treatment group had fewer proven fungal infections, fewer infusion-related side effects and le...
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ژورنال
عنوان ژورنال: Clinical Infectious Diseases
سال: 1999
ISSN: 1058-4838,1537-6591
DOI: 10.1086/313555